Catalog Number: TP-241

Size: Protein A purified rabbit immunoglobulins, 0.2 mg

Product Description and Usage: For research use only. This polyclonal antibody, which reacts with mouse BLC, was generated using E. coli-expressed mouse BLC as an immunogen. The tested titer forWestern blot is 1:5,000. Cross-reactivity to BLC of other species has not been determined.

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Background: BLC (B-lymphocyte chemoattractant, murine equivalent of human B cell-attracting chemokine-1, BCA-1) is a 12 kDa, recently characterized ELR-CXC chemokine. BLC showed high levels of expression in spleen, Peyer's patches, and mesenteric lymph nodes. It is reported as the ligand of CXCR5. It attracts primarily B cells in vitro. Cell lines transfected with CXCR5 demonstrate both chemotaxis and calcium flux in response to BLC.

References:

1. Gunn, M., et al. (1998) A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 391:799-803

2. Legler, D., et al. (1998) B cell attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med. 187(4):655-660

Catalog Number: TP-214

Size: Purified rabbit immunoglobulins, 0.5 mg

Product Description and Usage: For research use only. This polyclonal antibody, which reacts with recombinant and natural human eotaxin, was generated using E. coli-expressed amino acid 1-74 of mature human eotaxin as an immunogen. The tested titer for Western blot is 1:5,000. There is no cross-reactivity to mouse eotaxin; cross reactivity to eotaxin of other species has not been determined.

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