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上海拜力生物科技公司
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Capture PR3-ANCA WIESLAB? (CAP PR3IU)
品牌:Svar Life Science
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Capture PR3-ANCA WIESLAB? (CAP PR3IU)

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Capture PR3-ANCA WIESLAB?

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Wieslab? Capture PR3-ANCA detects antibodies to clinically relevant epitopes with high sensitivity and specificity. It’s prognostic correlations when it comes to relapse (no risk for relapse when negative) and level (high level correlates to outcome) are supported by publications. Wieslab? Capture PR3-ANCA is calibrated against the AF-CDC international standard, code IS2721 (Human Reference Serum 16).

Product code
CAP PR3IU
Format
ELISA
Tests
96 wells
Calculation
Quantitative
Antigen
Purified PR3 antigen
Units
IU/mL
Calibrators
6
Range
0-200 IU/mL
Incubation time
60+30+30 min
Detection system
405 nm
Availability
Cap PR3 IU: CE marked.
  • Intended use
  • Product Details

Intended use

The Wieslab? Capture PR3-ANCA test kit is an enzyme-linked immunosorbent assay (ELISA) for detection and quantitation of IgG antibodies to proteinase 3 (PR3) in human sera. The assay is used to detect antibodies in a single serum specimen. The results of the assay are to be used as an aid to the diagnosis of Wegener’s granulomatosis. It is not intended for screening a healthy population. The analysis should be performed by trained laboratory professionals.

FOR IN VITRO DIAGNOSTIC USE.

 

Background

ANCAs (anti-neutrophil cytoplasmic antibodies) are a family of autoantibodies related to vasculitis and inflammatory disorders. Since 1985, when c-ANCA was shown to be related to granulomatosis with polyangiitis (Wegener’s granulomatosis (WG)), interest in ANCAs has steadily increased, and today these antibodies are considered to be a major diagnostic tools for the diagnosis and follow up of systemic vasculitis.

The first method to detect ANCA was indirect immuno-fluorescence (IIF) performed on ethanol fixed granulocytes. This method yields two patterns, a cytoplasmic staining of the granulocyte denoting the presence of c-ANCAs, and a perinuclear staining denoting the presence of p-ANCAs. IIF was followed by ELISAs using the purified proteins.

The granulocyte is full of granules each with many different proteins. It was early shown that antibodies from systemic vasculitis patients bind to the alpha fraction containing theazurophil granules. The most important proteins were PR3 and myeloperoxidase (MPO). Thus antibodies to proteinase 3 are termed PR3-ANCA, and antibodies to myeloperoxidase are termed MPO-ANCA.

Approximately 80-90% of granulomatosis with polyangiitis (WG) patients manifest PR3-ANCA and 5-15% MPO-ANCA. One category of vasculitis is microscopic polyangiitis (MP). Most patients with active MP are characterised by positive ANCA test results, MPO-ANCA being more frequent than PR3-ANCA.

An international workgroup has developed an international standard for PR3-ANCA serology. The Wieslab? PR3-ANCA is calibrated against the AF-CDC international standard, code IS2721 (Human Reference Serum 16).

 

Technical information

The wells of the microtitre plate are coated with purified anti-PR3 monoclonal antibody and proteinase 3. During the first incubation, specific antibodies in diluted serum, will bind to the antigen coating.

The wells are then washed to remove unbound antibodies and other components.

A conjugate of alkaline phosphatase-labelled antibodies to human IgG binds to the antibodies in the wells in the second incubation.

After a further washing step, detection of specific antibodies is obtained by incubation with substrate solution. The amount of bound antibodies correlates to the colour intensity and is measured in terms of absorbance (optical density (OD)). The absorbance is then calculated against a calibrator curve and the results are given in IU/mL.

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