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訂購信息
上海拜力生物科技公司
Tel:400-968-7988    021-33779008
OTX015,BETInhibitor
品牌：Xcessbio
貨號：60193-2s
規格：2 mg solid
貨期：

OTX015,BETInhibitor
商品詳情 參考文獻 相關資料
Product Information
Molecular Weight: 491.99
Formula: C25H22ClN5O2S
Purity: ≥98%
CAS#: 202590-98-5
Solubility: DMSO up to 100 mM
Chemical Name: (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

OTX015 is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC50 of 10-19 nM. It inhibits the growth of a variety of human cancer cell lines with IC50 ranging from 60 to 200 nM. OTX015 results in rapid down-regulation